In 33 hypercholesterolemic patients, EVOO enriched with polyphenols led to an increase in HDL and antioxidant capacity [79], and in cells of patients with ulcerative colitis, cells stimulated with 3 mM oleuropein demonstrated reduced production of TNF-, IL-1, IL-17 and COX-2 [80]. The protein type within a hypocaloric diet affects obesity-related inflammation: The RESMENA project. with the supplementation of apple or apple pomace [59]. Miao X., Wang Y., Sun J., Sun W., Tan Y., Cai L., Zheng Y., Su G., Liu Q., Wang Y. Zinc protects against diabetes-induced pathogenic changes in the aorta: Roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2. Similarly, Mutairi et al. Finicelli M., Squillaro T., Di Cristo F., Di Salle A., Melone M.A.B., Galderisi U., Peluso G. Metabolic syndrome, mediterranean diet, and polyphenols: Evidence and perspectives. The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease. Accessibility Steinbrenner H., Speckmann B., Klotz L.O. In addition, bariatric surgery, particularly gastric bypass, reduces the risk of developing psoriasis (HR: 0.52) [155]. Determinants of vitamin D status in Caucasian adults: Influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors.
creams Armstrong A.W., Harskamp C.T., Armstrong E.J. Anemia, serum vitamin B12, and folic acid in patients with rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus. Anti-inflammatory effects of sodium butyrate on human monocytes: Potent inhibition of IL-12 and up-regulation of IL-10 production. Reynolds C.M., McGillicuddy F.C., Harford K.A., Finucane O.M., Mills K.H., Roche H.M. Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. Rajkumar H., Mahmood N., Kumar M., Varikuti S.R., Challa H.R., Myakala S.P. On the contrary, a study from Kurd et al. Gupta A.K., Ellis C.N., Tellner D.C., Anderson T.F., Voorhees J.J. Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasis. Lyte J.M., Gabler N.K., Hollis J.H. showed that obesity is associated with a two-fold increased risk of psoriasis compared to individuals with normal body weight. sharing sensitive information, make sure youre on a federal Polyphenols are the most abundant antioxidants in diet, with their main sources being fruits, vegetables, red wine, nuts, green tea, and olive oil. Bahraini et al. The amount, quality and dietary source of carbohydrates are the factors which determine their inflammatory capacity. Neuhouser M.L., Schwarz Y., Wang C., Breymeyer K., Coronado G., Wang C.Y., Noar K., Song X., Lampe J.W. Dalgard C., Nielsen F., Morrow J.D., Enghusen-Poulsen H., Jonung T., Horder M., de Maat M.P. At disease relapse the patient was treated with very-low-carb (300 Kcal/day), carbohydrate-free, high-protein (1.2 g per kilogram of ideal body weight) and low-fat diet as an add-on strategy to biological therapy. Of all its components, extra virgin olive oil seems to play the most important role in its anti-inflammatory capacities [173]. However, such high doses which cannot readily be implemented in everyday practice doubt the clinical significance of these results. Even more interestingly, a study by Kyriakou et al. Bach-Faig A., Berry E.M., Lairon D., Reguant J., Trichopoulou A., Dernini S., Medina F.X., Battino M., Belahsen R., Miranda G., et al. Impact of obesity and smoking on psoriasis presentation and management. SFAs are also related to inflammasome-mediated inflammation, as it was shown in a mouse model, where animals fed with a high-fat diet (45% PA) showed enhanced TLR4-dependent NLRP3-inflammasome activation and IL-1 secretion from dendritic cells [29]. Bilia A.R., Bergonzi M.C., Isacchi B., Antiga E., Caproni M. Curcumin nanoparticles potentiate therapeutic effectiveness of acitrein in moderate-to-severe psoriasis patients and control serum cholesterol levels. Serwin A.B., Wasowicz W., Gromadzinska J., Chodynicka B. Selenium status in psoriasis and its relations to the duration and severity of the disease. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. The adherence to MD leads to decreased risk for metabolic, cardiovascular and chronic degenerative diseases, possibly due to the main components of MD which have anti-inflammatory properties [169,170,171,172]. Improvement in a patient with pustular psoriasis. Research data regarding the effect of n-3 polyunsaturated fatty acids on the treatment of psoriasis are inconsistent. In the more recent HUNT study with 33.734 patients, Snekvik et al. reported that the cumulative consumption of 0.9 g/d EPA/DHA in 17 patients with psoriasis for 4 months led to moderate-excellent improvement in 10 of them; in a similar study, the supplementation at the dose of 1.9 g/d showed a significant decrease in PASI score after 4 and 8 weeks. Such results by single studies have been confirmed in a large meta-analysis including 54 studies and 19.372 patients, which showed that obesity is associated with 60% higher odds of inadequate response to anti-TNF treatment as compared to normal BMI; for each unit increment of BMI, there is an augmentation in odds of failure by 6.5% [137]. Ggebakan O., Kohl A., Osterhoff M.A., van Baak M.A., Jebb S.A., Papadaki A., Martinez J.A., Handjieva-Darlenska T., Hlavaty P., Weickert M.O., et al. Crosstalk between skin inflammation and adipose tissue derived products: Pathogenic evidence linking psoriasis to increased adiposity. Oliveira A., Monteiro V., Navegantes-Lima K.C., Reis J.F., Gomes R.S., Rodrigues D., Gaspar S., Monteiro M.C. Four-weeks of VLCKD resulted in 10% weight loss, 50% reduction in PASI score, improvement of biochemical markers related to psoriasis (folic acid, vitamin B12, cortisol, bilirubin, calcium, LDL, cholesterol) and decreased IL-1 and IL-2 levels [189].
Edrisi F., Salehi M., Ahmadi A., Fararoei M., Rusta F., Mahmoodianfard S. Effects of supplementation with rice husk powder and rice bran on inflammatory factors in overweight and obese adults following an energyrestricted diet: A randomized controlled trial. Kechichian E., Ezzedine K. Vitamin D and the Skin: An Update for Dermatologists. Gorjao R., Hirabara S.M., de Lima T.M., Cury-Boaventura M.F., Curi R. Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. Resveratrol Role in Autoimmune Disease-A Mini-Review. Plasma lycopene is associated with pizza and pasta consumption in middle-aged and older african american and white adults in the southeastern USA in a cross-sectional study. Renner S., Rath R., Rust P., Lehr S., Frischer T., Elmadfa I., Eichler I. Skyvalidas D.., Mavropoulos A., Tsiogkas S., Dardiotis E., Liaskos C., Mamuris Z., Roussaki-Schulze A., Sakkas L.I., Zafiriou E., Bogdanos D.P. A few studies have reported an association between psoriasis and Vitamin B12 deficiency [206,207,208]. An RCT including 18 patients with severe stable plaque psoriasis showed that fish oil supplementation in combination with UVB has beneficial effects on the clinical manifestations of psoriasis compared to the combination of olive oil with UVB [226]. Despite the lack of large randomized clinical trials to confirm the effect of different diets in patients with psoriasis, an abundance of research data highlights diet as a potential therapeutic target. The consumption of oily fish led to modest significant clinical improvement compared to white fish diet. As a result, a recommendation for selenium supplementation in patients with psoriasis cannot be established. Tungland B. Short-Chain Fatty Acid Production and Functional Aspects on Host Metabolism. Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review. Mostafa W.Z., Hegazy R.A. Vitamin D and the skin: Focus on a complex relationship: A review. Montonen J., Knekt P., Jrvinen R., Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. The .gov means its official. Yoshida H., Yanai H., Ito K., Tomono Y., Koikeda T., Tsukahara H., Tada N. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Aleixandre A., Miguel M. Dietary fiber and blood pressure control. Vitamin C is a potent ROS scavenger and stimulates neutrophil apoptosis and T-cell maturation, and its increased dietary intake has been associated with lower levels of CRP and PAI-1 [103,104,105]. In particular, a lower percentage of patients with psoriasis consumed extra virgin oil (as main lipid), fruits (3 portions/day), nuts (3 servings/week), fish or seafood (3 portions/week). Moreover, plasma EPA levels increased in patients with oily fish intake [211]. Holick M.F.
Association between coeliac disease and psoriasis: Italian primary care multicentre study. Vitamin C promotes maturation of T-cells. Carr A.C., Maggini S. Vitamin C and Immune Function. The results regarding the parenteral application of n-3 FAs are more encouraging compared to the mostly negative results of oral supplementation, probably because of the swift and sustainable increase in plasma levels of n-3 PUFASs leading to enhanced immune responses [223,224,225]. On the contrary, a double-blinded controlled study by Baker et al. Juhlin et al. Darghosian L., Free M., Li J., Gebretsadik T., Bian A., Shintani A., McBride B.F., Solus J., Milne G., Crossley G.H., et al. As inflammation is modulated by nutrition, it comes as no surprise that the impact of diet on the incidence and severity of the disease as well as on treatment response has been a matter of extensive research [13]. Patients with obesity and increased waist circumference have an almost two-fold risk for developing psoriasis, with relative risks being 1.87 and 1.95, respectively. Loued S., Berrougui H., Componova P., Ikhlef S., Helal O., Khalil A. Extra-virgin olive oil consumption reduces the age-related decrease in HDL and paraoxonase 1 anti-inflammatory activities. government site. Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine. Lastly, not all patients equally respond to vitamin D administration, a fact which may be attributed to vitamin D receptor (VDR) polymorphisms. Kiecolt-Glaser J.K., Belury M.A., Andridge R., Malarkey W.B., Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial. Adipocytokines, which are secreted not only by adipocytes but also by macrophages in adipose tissue, contribute equally to the inflammation process [141]. In a randomized controlled trial (RCT) in healthy adults, a 4-month supplementation of n-3 fatty acids of 2.5 g/d and 1.25 g/d versus placebo resulted in a significant decrease in IL-6 levels by 10% and 12% in the low and high dose n-3 FAs groups, respectively, compared to a 36% increase in the placebo group [31]. PMC legacy view [236], including 34 patients with psoriatic arthritis, a 24-week zinc supplementation improved joint pain and mobility and alleviated joint swelling. Neustadt J. On the other hand, research data about zinc seem to be more consistent. Effects of beta-carotene supplementation for six months on clinical and laboratory parameters in patients with cystic fibrosis. in BALB/c mice, which were topically treated with imiquimod for 6 consecutive days, treatment with EGCG attenuated skin inflammation and reduced skin infiltration of T cells, IL-17, IL-22, IL-23 and MDA levels, and increased SOD and CAT bioactivities [249]. Similarly, in a 12-week study, subjects who received n-3 supplementation showed a 14% decrease in lipopolysaccharide (LPS) stimulated interleukin 6 (IL-6) production, while a decrease in the n-6:n-3 ratio led to reductions in stimulated IL-6 and TNF- production [32]. Omega-3 fatty acids are generally considered to have anti-inflammatory capacities compared to omega-6 ones, although this is not always the case. PREDIMED Study Investigators Polyphenol intake and mortality risk: A re-analysis of the PREDIMED trial. Collier et al. Muscogiuri G., Barrea L., Laudisio D., Pugliese G., Salzano C., Savastano S., Colao A. Hjgaard P., Glintborg B., Kristensen L.E., Gudbjornsson B., Love T.J., Dreyer L. The influence of obesity on response to tumour necrosis factor- inhibitors in psoriatic arthritis: Results from the DANBIO and ICEBIO registries. However, according to an older study in 69 patients, selenium and Vitamin E supplementation for 12 weeks did not reduce psoriasis severity [233]. showed that intramuscular administration of vitamin B12 for 3 weeks offered no benefit to psoriatic patients [210]. Another prospective study showed that a weight loss >5% is significantly associated with the achievement of minimal disease activity as a response to anti-TNF treatment in obese patients with psoriatic arthritis [158].
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