Toh, Y.C., Xing, J. and Yu, H., 2015. Lor Huai Chong, Celine Ng, Huan Li, Edmund Feng Tian, Abhishek Ananthanarayanan, Michael McMillian, Yi-Chin Toh, Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites, 2019,ACS Omega,4, 9, 13902-13912. They developed a highly-customizable, 3D-printed peristaltic pump kit. A gel-free 3D microfluidic cell culture system, 2008,Biomaterials, 29(22): 3237-3244, Toh, Y.C., Zhang, J., Khong, Y.M., Du, Y., Sun, W. and Yu, H., 2008. Spatially organizedin vitromodels instruct asymmetric stem cell differentiation, 2011,Integrative Biology, 3: 1179-1187, Toh, Y.C., Kang, T.G., van Noort, D., Burkholder, B. and Zhang, J.B., 2011. Enzyme and Microbial Technology, 2003, 33(5): 569-575. To make microfluidic pumps more accessible to the scientific community, Singapore University of Technology and Design (SUTD) researchers have developed a highly-customizable and Arduino-powered peristaltic pump kit. Seep Arora, Akshaya Srinivasan, Chak Ming Leung,Yi-Chin Toh*, Bio-mimicking shear stress environments for enhancing mesenchymal stem cell differentiation, 2020, Current Stem Cell Research & Therapy, 15(5):414-427. Terry Ching, Jyothsna Vasudevan, Hsih Yin Tan, Chwee Teck Lim, Javier Fernandez, Yi-Chin Toh*, Michinao Hashimoto, Highly-customizable 3D-printed peristaltic pump kit, 2021,HardwareX, e00202. Using a modular design, the kit is easily customizable, easy to replace, and has exceptional forward compatibility. In 2020, he joined Shrike Zhangs Laboratory at Harvard Medical School as a visiting research trainee, working on light-based 3D bioprinting. Prof Lim has co-founded six startups which are commercializing technologies developed in his lab. Her research interest is in engineering multi-scale tissue models to mimic complex biological interactions during human development and diseases, as well as translating them into scalable platforms for disease modeling and drug testing applications. Dr Toh is a recipient of the Australia Research Council Future Fellowship, National University of Singapore Research Scholarship, A*STAR Graduate Scholarship and A*STAR International Fellowship. and Yu, H., 2013. Hsih Yin Tan and Yi-Chin Toh*, What can microfluidics do for microbiome research? To demonstrate the forward compatibility, we developed a flowrate calibration tool that was readily interfaced with the developed pump system. By evaluating NE tissue structural dysmorphia in the micropatterned NE model, we can successfully model gene- and drug-induced neurodevelopmental defects. At the same time, it generated tremendous respect for all the design engineers who used to work in the dark ages of electronics before HDL and EDA. By applying the modularized approach, 2D and 3D networks of microchannels with high complexity (i.e., multiple branching networks) and small crosssectional dimensions (w=75m and h=100m) are fabricated in photoresins and hydrogels. Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction, 2011,FASEB Journal, 25: 1208-1217, Toh, Y.C., Blagovi, K. and Voldman, J., 2010. Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules. Tasnim, F., Toh, Y.C., Qu, Y., Li, H., Phan, D., Narmada, B.C., Ananthanarayanan, A., Mittal, N., Meng, R.Q. Microfluidic systems for lab-on-a-chip (LoC) and organs-on-a-chip (OoC) applications require precise fluid flow control. The controlled presentation of TGF-b1 to hepatocytes in a 3D microfludic cell culture system, 2009,Biomaterials, 2009, 30: 3847-3853, Zhang, S., Xia, L., Kang, C.H., Xiao, G., Ong, S.M.,Toh, Y.C., Leo, H.L., van Noort, D., Kan, S.H., Tang, H.H. Yi-Chin Toh, Anju Raja, Hanry Yu, Danny van Noort, A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion, 2018, Bioengineering, 5(2): 29, Live visualisation and tracking of breast cancer cells migrating across an ECM barrier in a microfluidic 3D tumor model, Srinivasan, A., Chang, S.Y., Zhang, S., Toh, W.S.,Toh, Y.C. A multiplex microfluidic platform to systematically investigate the dosetime shear responses on hPSCEC morphology and arterialvenous phenotypes over a range of magnitudes coincidental with physiological levels of embryonic and adult vasculatures. She completed her Masters degree from the Department of Biomedical Engineering at The National University of Singapore (NUS).
Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection, 2008,Analyst, 133: 326-330, Wen, F., Chang, S.,Toh, Y.C., Arooz, T., Zhuo, L., Teoh, S.H. Wen, F., Chang, S.,Toh, Y.C., Teoh, S.H. *, Substrate stiffness modulates the multipotency of neural crest derived human ectomesenchymal stem cells via CD44 mediated PDGFR signaling, 2018,Biomaterials167:153-167. Being Restless and curious, I invested my time and solved it. 2007,Lab on a Chip, 7(3): 302-309. Thanks to Mr. Gustavo for designing such a wonderful course. He is also the Director of the Institute for Health Innovation and Technology (iHealthtech) and Founding Director of the Singapore Health Technologies Consortium. Javiers research at SUTD is focused on the broadstudy, development, and application of biological materials in science and technology. Seep, Evelyn Yim, Yi-Chin Toh*, Environmental specification of pluripotent stem cell derived endothelial cells towards arterial and venous subtypes,2019, Frontiers in Bioengineering and Biotechnologyhttps://doi.org/10.3389/fbioe.2019.00143. Shrilk is referred, for example, to as one of the materials that will change the future of manufacturing (Scientific American), a Supermaterial (National Geographic), and has been chosen (with graphene) one of the five material that could change the word (The Guardian). This paper describes a modular microfluidic platform that enables a user-intuitive and flexible way to configure multi-organ perfusion culture systems. This paper discusses how microfluidic technologies can value add to the different phases of human microbiome research as well as the unique challenges that microfluidics must overcome when working with microbiome-relevant biological materials. 2016,JoVE (Journal of Visualized Experiments), 112: pp.e54097-e54097. In this paper, we detail the fabrication and operation of two variations of pumps with different flow rates using the developed kit.
Application of polyelectrolyte complex coacervation to improve the seeding efficiency of bone marrow stromal cells in 3D scaffolds. Cellular responses to a nanofibrous environment, 2006,NanoToday, 1(3): 34-43. In 2014 he was awarded the worlds most outstanding young researcher in materials science by the Bayer Foundation. Our generation is blessed enough to leverage the advantage of Automation tools. While miniature pumps are commercially available, they require proprietary and expensive control systems.
In this paper, we combine hPSC micropatterning and a temporallysequenced induction protocol to specify neuroepithelial (NE) cells in spatial juxtaposition to mesoendoderm cells. Commercially available peristaltic pumps for microfluidics are usually bulky, expensive, and not customizable. After his Ph.D, Javier moved to MIT, where he developed the Micro-Masonry, a technology to assemble artificial organs and recognized as breakthrough in tissue engineering (CNET). A Configurable 3D Microenvironment in a Micro-fluidic Channel forPrimary Hepatocytes Culture. Before joining QUT, she led an independent research group as an Assistant Professor at the Department of Biomedical Engineering, National University of Singapore. Later, he moved to the Wyss Institute at Harvard University, where he designed and made Shrilk, a compostable and biocompatible material inspired by the insect cuticle. | Insanely Complex, Abbott Launches 5-Minute Virus Test for Use Almost Anywhere, How a Computer Chip Can Smell without a Nose. Scientific Reports,7. Fluorescence-based assays have long being used to assess cell viability in microfluidic devices. He has authored over 400 peer-reviewed journal papers and delivered more than 390 plenary/keynote/invited talks. Sahni, G.,Yuan, J.andToh, Y.C. .hide-if-no-js {
Geetika Sahni, Shu-Yung Chang1, Jeremy Teo Choon Meng, Jerome Zu Yao Tan, Jean Jacques Clement Fatien, Carine Bonnard, Kagistia Hana Utami, Puck Wee Chan, Thong Teck Tan, Umut Altunoglu, Hlya Kayserili, Mahmoud Pouladi, Bruno Reversade, Yi-Chin Toh*, A micropatterned human-specific neuroepithelial tissue for modeling gene and drug-induced neurodevelopmental defects, 2021, Advanced Science, https://doi.org/10.1002/advs.202001100. I want to present my gratitude to IBM for arranging such a fantastic workshop. #semiconductor Jyothsna joined The Fermart Lab in 2016 as NUS-SUTD PhD fellow. Happy 50th Birthday 4004 microchip! Kim, L.,Toh, Y.C., Voldman, J. and Yu, H., 2007. Hsih-Yin Tan received her PhD from Micro- and Nanotechnology Department (current Department of Health Technology from Denmarks Tekniske Universitet, Denmark in 2016. Prior to her research stint at NUS, she completed her Bachelors degree in Biotechnology from SRM University, Chennai.
Currently, his groups research directions include 3D printing and bioprinting for microfluidic devices, low-cost instrumentation, flexible devices, and 3D food printing. Featured in RSCs Chemical Biology, 2007, Issue 4Featured in RSCs Chemical Biology, 2007, Issue 4. His other hobbies include soccer, table tennis, and graphics design. Toh, Y.C., Ho, S.T., Zhou, Y., Hutmacher, D.W. and Yu, H., 2005. She is also an aspiring photographer. Rapid customization of the instrument would benefit users. I am glad to share that I have completed a summer internship Qiskit where I learn various topics in Quantum Computers. The assembled pumps offered a flowrate of 0.02 ~ 727.3L/min, and the smallest pump assembled with this kit was 205028mm. and Yu, H., 2016. Louis Jun Ye Ong, Liang Zhu, Gabriel Jenn Sern Tan,Yi-Chin Toh*, Quantitative Image-Based Cell Viability (QuantICV) Assay for Microfluidic 3D Tissue Culture Applications, 2020,Micromachines, 11 (7): 10.3390/mi11070669. 2016,Molecular Pharmaceutics,13(6), pp.1947-1957. Decolourisation of azo dyes by white-rot fungi (WRF) isolated in Singapore. 2005,Biomaterials,26(19): 41494160. Terry Ching, Yingying Li, Rahul Karyappa, Akihiro Ohno, Yi-Chin Toh, Michinao Hashimoto, Fabrication of Integrated Microfluidic Devices by Direct Ink Write (DIW) 3D Printing, 2019, Sensors & Actuators B: Chemicalhttps://doi.org/10.1016/j.snb.2019.05.086. She obtained her B.Eng in Chemical Engineering and Ph.D in Bioengineering from the National University of Singapore in 2001 and 2008 respectively. His research focuses on novel 3D printing methods to fabricate microfluidics, organs-on-a-chip, and biomimetic vasculature. This paper investigates the potential of neural crest derived human ecto-mesenchymal stem cells (eMSCs) for future clinical use in craniofacial regeneration applications and indicates the importance of considering MSC origin when selecting an MSC source for regenerative applications. *, Leo, H.L. 2021 The Authors. *,A 3D Printed Microfluidic Perfusion Device for Multicellular Spheroid Cultures, 2017,Biofabrication, Ong, L.J.Y., Chong, L.H., Jin, L., Singh, P.K., Lee, P.S., Yu, H., Ananthanarayanan, A., Leo, H.L.,Toh, Y.C. He has been also awarded with theZwick Science Awardfor his studies on Mechanical Testing, and best PhD thesis at the University of Barcelona for studies in the use of biopolymers inMicroelectronicsandBiomedicine. Toh, C. Zhang, J. Zhang, Y.M. Louis Jun Ye Ong, Terry Tsz Him Ching, Lor Huai Chong, Seep Arora, Huan Li, Ramanuj DasGupta, Po Ki Yuen, Yi-Chin Toh*, Self-Aligning Tetris-Like (TILE) Modular Microfluidic Platform for Mimicking Multi-Organ Interactions, 2019, Lab on a Chip,19, 2178-2191, 10.1039/C9LC00160C. From a 4-bit CPU that clocked a whopping 740 kilohertz, capable of executing 92,000 instructions per second and accessing 4KB of program memory and 640 bytes of RAM to a a chip with up to 16 cores and 24 threads, 5.2 gigahertz turbo frequency, 30MB shared Intel Smart Cache, DDR5 memory and both PCIe 4.0 and 5.0 for the latest storage and high-performance discrete graphics (Intel 12th Gen) This study is a comprehensive evaluation of the effects of various topographical cues on arterial- or venous-specific EC phenotype and function. Akshaya Srinivasan, Nelson Teo, Poon Kei Jun, Priya Tiwari, Akhilandeshwari Ravichandran, Wen Feng, Swee Hin Teoh, Thiam Chye Lim, Yi-Chin Toh*, Comparative Craniofacial Bone Regeneration Capacities of Mesenchymal Stem Cells Derived from Human Neural Crest Stem Cells and Bone Marrow, 2021, ACS Biomaterial Science and Research, 7, 1, 207221. Seep Arora, Christine Cheung, Evelyn Yim*, Yi-Chin Toh*, Topography elicits distinct phenotypes and functions in human primary and stem cell derived endothelial cells, 2020, Biomaterials, 234, 119747. Tasnim, F., Phan, D., Toh, Y.C. A method for human teratogen detection by geometrically confined cell differentiation and migration. Leveraging on being smallSingapores strategy to catalyze integrative innovations, 2011,Lab on a Chip, 11: 1853-1855(Invited article), Toh, Y.C. Download : Download high-res image (220KB)Download : Download full-size image. Professor Lim is the inaugural NUSS chair Professor at the Department of Biomedical Engineering and Founding Principal Investigator at the Mechanobiology Institute. Moores Law is alive and well. His research was cited by the MIT Technology Review magazine as one of the top ten emerging technologies of 2006 that will have a significant impact on business, medicine or culture.. This cost-effective, highly customizable pump kit should find use in lab-on-a-chip, organs-on-a-chip, and point-of-care microfluidic applications. This paper demonstrates the generation and quantification of immunogenic metabolite species of paradigm skin sensitising drugs using a human progenitor cell (HepaRG)-derived hepatocyte model and highly sensitive liquid chromatography-mass spectrometry analytical assays. and Yu, H., 2013. Xing, J.,Toh, Y.C., Xu, S. and Yu, H., 2015. Protecting Your Internet-Connected Devices From Threats, Twin Gene-Editing System Gives Twice The Efficiency, Space Exploration Educators Conference 2019, Why Renewable Energy Is Essential To Curbing Climate Change, Self-Driving Cars That Recognize Free Space Can Better Detect Objects, Genetics Influences Where People Choose To Live. Microfabricated silicon nitride membranes for hepatocyte sandwich culture, 2008,Biomaterials, 29 (29): 3993-4002, Zhao, D., Ong, S.M., Yue, Z., Jiang, Z.,Toh, Y.C., Khan, M., Shi, J., Tan, C.H., Chen, J.P. and Yu, H., 2008. ScienceDirect is a registered trademark of Elsevier B.V. ScienceDirect is a registered trademark of Elsevier B.V. Highly-customizable 3D-printed peristaltic pump kit. It is comparable to commercially available options at a fraction of the cost, estimated at US$50 per pump. This resulted in the formation of a reproducible and highlyorganized NE tissue.
Today my grandkids can explore the universe from a handheld computer. We use cookies to help provide and enhance our service and tailor content and ads.
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